BiomedicalScientist

Chronological ageing is a biological process that results in accumulated cellular damage, ultimately driving the onset of metabolic disfunction. We aim to develop new therapeutic approaches to these ageing-associated diseases, by targeting metabolism in cancer stem cells (CSCs) and senescent fibroblasts. More specifically, we will screen a series of chemical libraries containing FDA-approved drugs, natural products, and novel chemical entities, to identify compounds that can effectively age-associated metabolic features. Through this screening and validation approach, we will identify compounds that preferentially kill CSCs and senescent fibroblasts, using established cell lines. This position will involve the screening and discovery of drugs that target the metabolic phenotype of senescent cells and cancer stem cells, across multiple cancer types. The purpose of this role is to support Lunella Biotech’s mission in the discovery of anti-ageing and anti-cancer therapeutics. In more detail, you will work as part of a team of scientists, and will be responsible for the co-planning and execution of many experimental aspects of the project. This position will involve the identification and phenotypic validation of drugs that target senescent cells and cancer stem cells. The project will require the use of immunohistochemistry, immunocytochemistry and flow cytometry applied to relevant samples. Responsibilities * To perform experiments in the laboratory to test hypotheses regarding ageing and cancer * To plan and execute the experiments related to the phenotypic validation of identified drugs targeting CSCs and senescent cells. * To apply complex research techniques for the phenotypic validation of drug hits using immunohistochemistry, immunofluorescence and flow cytometry of relevant samples. * Take overall responsibility for several experimental components of the project. * To maintain accurate records of data and analysis performed of specific experiments for a given p