Takeda
Pharmaceutical Sciences
AssociateScientist,ADMEandAssayDevelopment
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“Associate Scientist, ADME and Assay Development at Takeda. Skills: ADME assays, Mass spectrometry, Assay development, Data analysis. Develop, miniaturize, optimize, and validate robust high-throughput ADME. Generate high-quality, reproducible ADME data”
What You'll Achieve.
Deliver differentiated medicines to the clinic at speed and cost; Generate high-quality, decision-enabling data; Ensure rigor, reproducibility and efficiency across programs; Accelerate discovery through automation & AI integration; Increase throughput; Reduce variability; Shorten DMTA cycle times; Ensure data quality & scientific rigor; Inform compound progression and portfolio decisions; Translate assay data into actionable insights; Support timely and informed advancement of discovery programs
Industry & Context.
Troubleshoot technical issues; Solve problems of moderate scope
What They're Looking For.
Must Have
Master's degree in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences or related discipline with 3+ years of relevant industry experience in drug discovery, Bachelor's degree with 5+ years of relevant industry experience in drug discovery, Develop, miniaturize and analyze ADME assays, Running high-throughput MS platforms, Method development, optimization, troubleshooting and routine operation, Working within DMTA-driven discovery workflows, Applies established scientific principles and standard techniques to perform and troubleshoot assays, Demonstrated ability to work independently and collaboratively in a highly matrixed, cross-functional environment while managing multiple priorities, Applies judgment within established procedures to solve problems of moderate scope
Nice to Have
Proficiency with MS data analysis tools, Experience with scripting or data handling, Familiarity with laboratory automation systems
What You'll Do.
and validate robust high-throughput ADME
Generate high-quality
reproducible ADME data
execute and support design of quantitative and
Perform and ensure timely execution of ADME assays
Communicate results effectively to program teams
Identify and troubleshoot up to moderately complex technical
Apply rigorous statistical analysis
Interpret complex datasets
Utilize automation platforms and laboratory instrumentation
Improve assay throughput
and present research findings
Sustain a high-performing and reliable laboratory environment
Apply quality control standards
Execute preventative maintenance of instrumentation
Ensure strict adherence to established standard operating procedures
Lead discrete assay activities or components of projects
Contribute to continuous improvement of assay workflows
Contribute to continuous improvement of laboratory practices
Contribute to continuous improvement of documentation
How You'll Work.
Team & Collaboration
Partner closely with DMPK, medicinal chemistry, data sciences, and early discovery teams; Collaborate closely with cross-functional teams
Communication Scope
Present research findings
Process & Methodology
DMTA cycles
Full Job Description
By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s [Privacy Notice](https://jobs.takeda.com/privacynotice) and [Terms of Use](https://www.takeda.com/terms-and-conditions/). I further attest that all information I submit in my employment application is true to the best of my knowledge. ## **Job Description** Takeda Research is constructing a Lab of Tomorrow built on AI, automation, new ways of working, and talent with the singular vision of delivering differentiated medicines to the clinic at speed and cost. _Objective / Purpose:_ The Associate Scientist will play a critical role in supporting ADME based high-throughput mass spectrometry screening and iterative Design–Make–Test–Analyze (DMTA) activities across small molecule programs. Operating within fully automated, integrated laboratory systems, this individual will develop and execute robust bioanalytical assays that generate high-quality, decision-enabling data for small molecule discovery. With strong expertise in statistical analysis to assess assay robustness and data quality as the ability to solve problems of moderate scope, the Associate Scientist will ensure rigor, reproducibility and efficiency across programs. Importantly, this role will play a key part in Takeda’s “Lab of the Future” initiative, driving implementation of highly efficient, AI-integrated DMTA cycles that accelerate innovation and enhance data-driven discovery. This role contributes to critical function delivery: * Accelerates Discovery Through Automation & AI Integration: Executes and contributes to fully automated, end-to-end ADME assay workflows integrated with AI-enabled analytics to increase throughput, reduce variability, and shorten DMTA cycle times. * Ensures Data Quality & Scientific Rigor: Applies statistical methodologies to evaluate assay performance (e.g., Z’, variability metr
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