GenScript/ProBio
Biotechnology
AssociatePrincipal/PrincipalScientist(ProteinScience)
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optimal for Principal candidates.
“Associate Principal / Principal Scientist (Protein Science) at GenScript/ProBio. Skills: Bispecific Antibody Design, Protein Science, Molecular Engineering. Develop innovative strategies for design and engineering of. Implement innovative strategies for design and engineering of”
Industry & Context.
Problem-solving skills; Troubleshooting
What They're Looking For.
Must Have
Ph.D. in Biochemistry, Molecular Biology, Cell Biology, Structural Biology, Bioengineering or related field, At least 5 years of experience in antibody design, protein expression, and purification, Expertise in bispecific design, Troubleshooting expression challenges, Demonstrated record of success with protein engineering for enhanced protein expression or properties, Experience with biophysical characterization of proteins, Experience with assessment of protein-protein interactions, Analytical and problem-solving skills, Wide ranging experience in analytical techniques, Excellent written and verbal English communication skills
Nice to Have
Experience in an industrial setting, Familiarity with automation and high-throughput techniques for protein expression and purification
What You'll Do.
Develop innovative strategies for design and engineering of
Implement innovative strategies for design and engineering of
Troubleshoot innovative strategies for design and engineering of
Design a portfolio of projects
Manage a portfolio of projects
structure-function insights
and manufacturability
Oversee a team of research associates
Oversee a team of biotechnologists
Provide technical guidance to team
Foster a culture of excellence in protein science
Collaborate with cross-functional teams
Collaborate with cross-cultural teams
Support the development of biologics
Evaluate new technologies
Translate new technologies into production-ready solutions
Review advancements in antibody formats
Review advancements in engineering strategies
Review advancements in upstream and downstream integration impacts
Assess readiness of new technologies for tech transfer
Assess fit-for-purpose application across different molecule classes
Assess scalability and reproducibility
Assess impact on quality attributes
Act as a scientific bridge between R&D and
Ensure new platforms are scientifically sound
Ensure new platforms are translatable to production workflows
Ensure design decisions align with manufacturing realities
Partner with internal stakeholders
Develop design-for-manufacturability strategies
Develop internal guidelines for manufacturability
Develop AI-assisted design-for-manufacturability frameworks
Integrate AI-assisted design-for-manufacturability frameworks
Leverage internal datasets
Leverage external computational tools
Proactively identify risks
Proactively mitigate risks
Lead AI-enabled design initiatives
Support AI-enabled design initiatives
Translate computational design outputs into experimentally validated constructs
Ensure alignment between in silico design predictions and
Contribute to intellectual property portfolio
Draft scientific papers
Report innovations in scientific forums
Contribute to development of scientific publications
Contribute to conference presentations
Contribute to webinars
Prepare technical reports
Review technical reports
Prepare technical documentation
Review technical documentation
How You'll Work.
Team & Collaboration
Cross-functional teams; Cross-cultural teams; Internal stakeholders; Quality Assurance; Process Development; Manufacturing
Communication Scope
Scientific publications; Conference presentations; Webinars; Technical reports; Technical documentation
Process & Methodology
Project management
Full Job Description
About GenScript GenScript Biotech Corporation (Stock Code: 1548.HK) is a global biotechnology group. Founded in 2002, GenScript has an established global presence across North America, Europe, the Greater China, and Asia Pacific. GenScript's businesses encompass four major categories based on its leading gene synthesis technology, including operation as a Life Science CRO, enzyme and synthetic biology products, biologics development and manufacturing, and cell therapy. GenScript is committed to striving towards its vision of being the most reliable biotech company in the world to make humans and nature healthier through biotechnology. Position Overview: We are seeking a highly motivated and experienced Principal Scientist in Bispecific Antibody Design & Engineering to establish and strengthen Singapore’s role as a center of excellence for complex antibody design and molecular engineering. In this role, you will serve as a functional leader in molecular design, format selection and recommendation, and engineering strategy while enabling improved expression, developability, and manufacturability. Additionally, you will play a key role in client-facing projects, ensuring seamless collaboration and delivery of high-quality biologics solutions. This position requires a blend of platform building, leadership skills, and the ability to build cross effectively. Key Responsibilities: Biologics Production Leadership: Develop, triage, implement, and troubleshoot innovative strategies for the design and engineering of complex antibody formats (bispecifics, multivalent, Fc-fusions, VHH). to achieve high yields, purity, and functionality. Design and manage a portfolio of projects to provide data-driven, structure-function insights to improve expression, stability, and manufacturability. Oversee a team of research associates and/or biotechnologists, providing technical guidance and fostering a culture of excellence in protein science methodologies. Cross-Functional Collaboration:
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