Sarepta
genetic medicine
AssociateEngineer,RNAStartingMaterialMS&T
Neural analysis suggests this role is
optimal for Entry candidates.
“Associate Engineer, RNA Starting Material MS&T at Sarepta. Skills: organic chemistry, process chemistry development, scale-up, analytical data interpretation. lab-scale organic synthesis, purification, analysis, and characterization of the nucleoside-based and lipid building blocks of Sarepta’s phosphorodiamidate morpholino oligomers (PMOs), next-generation PMO, and siRNA platforms. synthesis of reference markers/standards”
What You'll Achieve.
Support commercial supply assurance for RNA starting materials by synthesizing nucleoside reference markers/standards; optimize and troubleshoot syntheses; support process improvements, troubleshooting, and technology transfers
Industry & Context.
excellent organic chemistry and problem-solving skills; troubleshoot syntheses; Use scientific judgement to determine likely source and fate of newly identified impurities and design experiments to test hypotheses
<5% infrequent domestic and/or international travel, This position requires work on site at one of Sarepta’s facilities in the United States.
What They're Looking For.
Must Have
B.S. in Chemical Engineering, Chemistry, or related discipline, 0-2 years related experience, Technical competence in organic chemistry, Able to handle multi-task workload and perform effectively under deadlines, Effective written and verbal communication skills, interpersonal skills and attention to detail are necessary, Candidates must be authorized to work in the U. S.
Nice to Have
Experience running HPLC methods is strongly preferred
What You'll Do.
lab-scale organic synthesis
and characterization of the nucleoside-based and lipid building blocks of Sarepta’s phosphorodiamidate morpholino oligomers (PMOs)
synthesis of reference markers/standards
participating in supervised RNA starting materials manufacturing process chemistry development and scale-up projects to optimize and troubleshoot syntheses
synthesis and purification (chromatography) of nucleoside analogs
documentation of study results
and presentation of data and conclusions
How You'll Work.
Team & Collaboration
work in a team focused on lab-scale organic synthesis; regular interaction with Analytical/QC resources; cross-functional training; design experiments to test hypotheses as part of a cross-functional team; Participate in vendor update meetings and provide input on ongoing vendor production projects
Communication Scope
Effective written and verbal communication skills; presentation of data and conclusions
Full Job Description
**Why Sarepta? Why Now?****** The promise of genetic medicine has arrived, and Sarepta is at the forefront. We hold a leadership position in Duchenne muscular dystrophy (Duchenne) and are building a robust portfolio of programs across muscle, central nervous system, and cardiac diseases. In 2023, we launched our fourth therapy and the first ever gene therapy to treat Duchenne. We’re looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients. **What Sarepta Offers** At Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. We are committed to offering a range of benefits and work-life resources designed to support people in the following areas: * Physical and Emotional Wellness * Financial Wellness * Support for Caregivers For a full list of our comprehensive benefits, see our website: [https://www.sarepta.com/join-us](https://www.sarepta.com/join-us) **The Importance of the Role** The Associate Engineer, RNA Starting Material MS&T will work in a team focused on lab-scale organic synthesis, purification, analysis, and characterization of the nucleoside-based and lipid building blocks of Sarepta’s phosphorodiamidate morpholino oligomers (PMOs), next-generation PMO, and siRNA platforms. The role will involve both synthesis of reference markers/standards and participating in supervised RNA starting materials manufacturing process chemistry development and scale-up projects to optimize and troubleshoot syntheses. The role will involve cross-functional training, regular interaction with Analytical/QC resources, and interpretation of HPLC, GC, KF, and NMR data. The position involves protocol and report writing a
Applying for this Associate Engineer, RNA Starting Material MS&T role?
Most applicants get filtered before a human reads their resume. See if yours makes the cut.
How to Apply on Workday
- Workday has a multi-step form — save your progress after every section.
- "Apply With LinkedIn" can fail or lose data; manual entry is more reliable.
- Watch for the "Submit for Review" final step — hitting "Save" alone does not submit.
- Job requisition numbers are useful when following up with HR by email.
ANONYMOUS · UNFILTERED
What do employees actually say about Sarepta?
Real rants from real employees. Read before you apply.