Sanofi
Biopharma
AI-EnablediPSCDiseaseModeling&FunctionalGenomics
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optimal for Senior candidates.
“AI-Enabled iPSC Disease Modeling & Functional Genomics at Sanofi. Skills: iPSC differentiation, CRISPR screening, Assay development, High-content imaging. Generate and validate isogenic iPSC lines. Differentiate iPSCs into CNS cell types”
What You'll Achieve.
Deliver fit-for-purpose assays; Drive internal discovery programs; Uncover genetic modifiers of disease-relevant phenotypes; Translate human cellular insights into actionable drug discovery hypotheses; Qualify assays for internal use
Industry & Context.
What They're Looking For.
Must Have
BS with 4+ years OR MS with 2+ years, of relevant laboratory experience in stem cell biology, neuroscience, molecular biology, cell biology, or a related discipline, Demonstrated hands-on proficiency in human iPSC culture, banking, karyotype/STR/pluripotency QC, and directed differentiation into at least one CNS cell type (microglia, astrocytes, oligodendrocyte-lineage cells, or neurons), Hands-on experience developing plate-based and/or high-content imaging assays, including assay miniaturization, Z’-factor and reproducibility assessment, and basic statistical interpretation of phenotypic data, Familiarity with high-content imaging platforms (e.g., Opera Phenix, ImageXpress, IN Cell, Yokogawa CV8000) and image analysis tools (Harmony, Columbus, CellProfiler, QuPath), organizational skills, meticulous record-keeping, ability to manage multiple parallel workflows in a deadline-driven environment, Excellent written and verbal comfort presenting data to scientific audiences
Nice to Have
Experience with co-culture, tri-culture, or organoid systems modeling neuron–glia interactions, Hands-on experience with CRISPR/Cas9 genome editing in human iPSCs, including guide design, delivery (RNP, lentiviral, or transfection), clone isolation, and validation of edited lines, Direct experience executing pooled or arrayed CRISPR screens, including library handling, transduction, selection strategy, NGS sample preparation, and first-pass analysis using MAGeCK or comparable tools, Background in neurodegenerative disease research, particularly TDP-43 proteinopathies, ALS, FTD, or related disorders, Working knowledge of R or Python sufficient to perform QC, generate exploratory plots, and interface with computational collaborators, Familiarity with AI/machine learning–based image analysis for cellular phenotyping, Experience with CRISPR activation/interference systems, Prior pharmaceutical or biotechnology industry experience and exposure to GLP/GxP-adjacent documentation practices, Co-authorship on peer-reviewed publications
What You'll Do.
Generate and validate isogenic iPSC lines
Differentiate iPSCs into CNS cell types
Develop and optimize co-culture systems
Build and validate cellular assays
Develop high-content imaging assays
Apply AI/machine learning image analysis
Execute pooled and arrayed CRISPR screens
Generate stable cell lines
Maintain electronic lab notebook records
Contribute to internal data reviews
Present results at meetings
Contribute to publications
Develop standard operating procedures
Train junior team members
Coordinate with external collaborators
How You'll Work.
Team & Collaboration
Partner with computational biologists; Partner with neuropathologists; Partner with program teams; Collaborate with screening and ADME groups; Collaborate with computational team members; Coordinate with external academic collaborators; Coordinate with CRO partners
Communication Scope
Excellent written communication; Excellent verbal communication; Presenting data to scientific audiences
Process & Methodology
Manage multiple parallel workflows, Deadline-driven environment
Full Job Description
**Job title** :_AI-Enabled iPSC Disease Modeling & Functional Genomics_ * _Location: Cambridge, MA_ **About the Job** Sanofi is building a next-generation neuroscience research engine focused on defining the molecular mechanisms of neurodegenerative disease — Alzheimer’s disease, ALS, frontotemporal dementia, Parkinson’s disease, and multiple sclerosis — through high-resolution interrogation of human models and tissue. We are seeking a Senior Research Associate II to develop and deploy human iPSC-derived cellular models and CRISPR-based functional genomics to interrogate TDP-43 biology and other priority pathways, and to deliver fit-for-purpose assays that drive internal discovery programs. This role sits at the experimental engine of the group. The successful candidate will design, generate, and characterize isogenic iPSC lines and iPSC-derived glial and neuronal cultures; build robust phenotypic assays suitable for hit-finding and target validation; and contribute to pooled and arrayed CRISPR screens that uncover genetic modifiers of disease-relevant phenotypes. The role partners closely with computational biologists, neuropathologists, and program teams to translate human cellular insights into actionable drug discovery hypotheses. Join the engine of Sanofi’s mission — where deep immunoscience meets bold, AI-powered research. In R&D, you’ll drive breakthroughs that could turn the impossible into possible for millions. **About Sanofi:** We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives. **Main responsibilities:** * Maintain, expand, and quality-control human iPSC lines; generate and validate isogenic disease-relevant lines using CRISPR/Cas9, base editin
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