Advisor
healthcare
Advisor-OligonucleotideAnalytics
Neural analysis suggests this role is
optimal for Entry candidates.
“Advisor - Oligonucleotide Analytics at Advisor. Skills: LC method development, LC-MS method development, oligonucleotide characterization, quality control. Design, develop, optimize, and standardize robust analytical and separation methods. Proactively evaluate and implement innovative analytical technologies”
Industry & Context.
resolve complex analytical challenges
predominantly lab-based role
What They're Looking For.
Must Have
PhD in Analytical Chemistry, Chemistry, Pharmaceutical Sciences, or a related scientific field, 1-4+ years of relevant post-graduate experience (including industry postdoctoral experience)
Nice to Have
Extensive experience in LC and LC-MS method development, optimization, and troubleshooting., Proficiency in the characterization of chemically modified oligonucleotides, conjugates, and related impurities., Understanding of structure–activity relationships (SAR) and developability assessments for therapeutic oligonucleotides., Proven track record in developing and validating a broad range of analytical and separation techniques, including LC, LC-MS, ion-pairing LC, SEC, CE, HILIC, HIC, and IEX., Demonstrated ability to assess and adopt emerging analytical technologies, such as high-resolution mass spectrometry, oligonucleotide mapping, intact mass analysis, and charge variant analysis., Hands-on experience operating, maintaining, and troubleshooting analytical and separation platforms, including UPLC, LC-MS, CE, MALS, and preparative HPLC., Familiarity with Agilent and Thermo instrumentation and associated software, including ChemStation, OpenLab CDS, MassHunter, and Xcalibur., Solid knowledge of analytical control strategies and quality standards applicable across early- and late-stage drug discovery., High degree of self-motivation with a demonstrated ability to independently lead and deliver complex scientific projects., written and verbal communication skills, with the ability to collaborate effectively across cross-functional teams., Open-minded, meticulous, and committed to continuous learning in a fast-paced, dynamic environment., Proven ability to manage multiple priorities, navigate ambiguity, and deliver high-quality results under tight timelines.
What You'll Do.
and standardize robust analytical and separation methods
Proactively evaluate and implement innovative analytical technologies
Maintain and troubleshoot analytical and separation instrumentation
Leverage deep expertise in oligonucleotide characterization and quality control
Partner with IT to build and maintain laboratory informatics systems
Continuously refine existing analytical methods and assays
Collaborate across chemistry
and technology platform teams
Rapidly integrate new technologies and apply cross-disciplinary scientific concepts
and prompt documentation of experiments
Uphold high standards of laboratory practice in compliance with safety and quality guidelines
Communicate findings and progress clearly and persuasively
How You'll Work.
Team & Collaboration
Partner with IT to build and maintain laboratory informatics systems; Collaborate across chemistry, biology, and technology platform teams; Communicate findings and progress clearly and persuasively through regular presentations at project team, departmental, and governance meetings.
Communication Scope
written and verbal communication skills; Communicate findings and progress clearly and persuasively
Process & Methodology
independently lead and deliver complex scientific projects, manage multiple priorities, navigate ambiguity, deliver high-quality results under tight timelines
Full Job Description
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. The Lilly Genetic Medicine RNA group at Lilly Seaport Innovation Center in Boston is seeking a highly skilled and motivated Analytical Scientist to join our team. The successful candidate will bring a strong track record in designing, developing, and implementing analytical and separation methodologies for the characterization and quality control of oligonucleotides and their conjugates. This is a predominantly lab-based role requiring deep expertise in LC and LC-MS method development, a solid understanding of oligonucleotide synthesis and downstream processing, and a commitment to advancing the science of complex, chemically modified oligonucleotides in support of RNA therapeutics. # Responsibilities * Design, develop, optimize, and standardize robust analytical and separation methods—including LC, LC-MS, CE, SEC/AEX-MALS and preparative HPLC systems—for sample quality control and the characterization of oligonucleotides and their conjugates across all stages of drug discovery. * Proactively evaluate and implement innovative analytical technologies to address challenges in the analysis of complex, modified oligonucleotides and drive continuous scientific advancement. * Maintain and troubleshoot analytical and separation instrumentation (e.g., UPLC, LC-MS, CE, and preparative HPLC) to ensure high performance, reliability, and minimal downtime in support of critical workflows. * Leverage deep expertise in oligonucleotide charac
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